POU5F1 and reproductive system disorder: When IPA was specifically interrogated with the list of these 25 genes, including Oct-4, it generated 6 networks (Table 3) with a score ≥ 2, of these, the first two contained 12 and 7 (including Oct-4 itself) focus genes respectively, and had top functions centred around biological themes such as gene expression, cell death, cancer and reproductive system disease.