Indeed, given the low–high and vice versa NO/TNFα regulatory correlation discussed earlier, together with established high levels of TNFα in sepsis [187], and observed 83% increase in spinal fluid TNFα levels in Cbl deficiency [188], the argument for NO overproduction in sepsis looks tenuous, whereas it has been shown that higher levels of ATP in septic patients have a positive significant correlation with survival [189]. Here, TNF is linked to Sepsis.