Rather, the problem may be a malfunction of iNOS, resulting from degrees of mild, subclinical or ‘functional’ Cbl deficiency, which might also involve ‘compartmental’ Cbl deficiency, with the local inactivation of one of the two Cbl coenzymes, MS in the CNS, for example [127], allied perhaps to other factors such as age, immune compromise, poor general nutritional status, and/or iNOS, TNFα, interferon, platelet activating factor, TC, gastric atrophy, or other, genetic polymorphisms. Here, NOS2 is linked to chronic atrophic gastritis.