Since continuously expressed iNOS in the latter locations clearly has a positive protective function, removed from persistent pathology, (the lungs are continuously exposed to pathogens and iNOS NO in bronchial epithelium [151], yet most people do not have asthma, for example,) iNOS must be very tightly regulated, with strong endogenous safeguards to prevent its malfunction. The gene discussed is NOS2; the disease is asthma.