Accordingly, recombinant IL-33 was found to drive production of pro-inflammatory and Th2-associated cytokines in mast cells and Th2 lymphocytes [2], [5]–[10], to induce chemotaxis of Th2 cells [11] and to protect the heart against cardiac stress [4] and atherosclerosis [12]. The gene discussed is IL33; the disease is atherosclerosis.