TP53 and colon adenocarcinoma: Search for downstream of p53 revealed that in mammary epithelial carcinoma and colon adenocarcinoma cells curcumin could increase the expression of the pro-apoptotic protein Bax and decrease the anti-apoptotic protein Bcl-2/Bcl-xL through the phosphorylation at Ser15 and activation of p53 [6,85].