Prasad et al [16] who reported that left dorsolateral prefrontal cortex (DLPFC) volumes were significantly different across first episode schizophrenia patients and controls on SNPs 4 (rs951436) and 18 (rs2661319) after correcting for multiple comparisons, indicating that these RGS4 polymorphisms may contribute to structural alterations in brain areas, previously associated with schizophrenia. The gene discussed is RGS4; the disease is schizophrenia.