CST3 and kidney disorder: Urinary function tests using sensitive early markers of renal disease (α1-microglobulin, β-N-acetyl-d-glucosaminidase (β-NAG), cystatin C) showed no impairment of renal function, and indicated that an oral OD dose of 3 g mesalazine, which is associated with higher peak-plasma levels as compared to a 1 g TID regimen, is at least as safe as a 1 g TID dose with regard to potential tubulo-toxicity.