So, the criteria of the WHO require the presentation of some alteration in carbohydrate metabolism, whether diabetes, abnormal glucose tolerance or resistance to insulin and two of the following criteria must also be taken into account: arterial hypertension > 140/90 mmHg, obesity (BMI = 30 kg/m2), hypertriglyceridemia ≥ 150 mg/dL or cHDL values < 35 in males and < 40 in females and microalbuminuria ≥ 20 μg/min. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.