At day 7 post infection, 5.4 (±1.7)% of CD8 T cells in the spleens of mice infected with 103.5 VACV-WR i.n. were B8R20–27 specific which was similar to the frequencies in mice given 103.5 vGK5 by the i.n. route (Fig. 2B). Here, CD8A is linked to infection.