TGFB1 and cancer: Tobin et al, (2002) observed a marked enhancement of tumour growth in vivo by tumour-derived TGF-β when an autocrine loop was left intact. Studies also found that increased production of TGF-β1 by tumour cells was associated with potential invasiveness and metastasis of cancer (Gorsch et al, 1992; Dalal et al, 1993; Ueki et al, 1993; Tobin et al, 2002).