A recent study demonstrated overexpression of NEK6 transcripts in hepatocellular carcinoma (Chen et al, 2006), although it was found to be frequently expressed among 125 serine/threonine kinase genes implicated in breast cancer, colorectal cancer, lung cancer, and laryngeal cancer by in situ hybridisation (Capra et al, 2006). This evidence concerns the gene MARK2 and breast cancer.