In breast cancer, several genes encoding inhibitors of canonical Wnt/β-catenin signalling have been reported to be frequently hypermethylated, for example, SFRP1 [34,41], SFRP2 [42], SFRP5 [43], WIF1 [44] and DKK1 [42]. This evidence concerns the gene SFRP1 and breast carcinoma.