We tested the impact of earlier diagnosis on the response to treatment, using data from the study of Kamal et al. 36 This study showed that PEG-IFN therapy induces high SVR rates and prevents CHC, and that SVR varied according to timing of therapy.36 Our analysis suggested that the alternative-US strategy would lead to a slightly lower number of CHC cases than the French and European strategies. Here, IFNA1 is linked to cryohydrocytosis.