Similarly, the NOS3 levels within the positive PCA3 class (grouping BPH and PCa patients) presented a linear behavior considering the -786T>C polymorphism, with higher levels (3.1) for the (-786T>C + -786T>C) mutant homozygous patients, followed by medium levels (2.3) for the (-786T>C + [=]) heterozygous and lower levels (1.5) for normal homozygous patients (Figure 5B). Here, PCA3 is linked to benign prostatic hyperplasia.