The suggestion that decreasing NOS3 expression levels, which consequently reduce the NO production, would have an anti-apoptotic role, and may promote tumor growth [32] may be explained in part by the bimodal behavior of the NOS3 levels across the stages as shown in this investigation and in a previous work [24], once lower levels is mainly seen in advanced tumor stages (pT3 and pT4). Here, NOS3 is linked to neoplasm.