Selected genes supplemented with others from relevant literature in human and murine models of TB, including those encoding molecules involved in pathogen recognition (TLR2, TLR4 and IL1R), signal transduction (MYD88, TOLLIP, and TICAM2), gene transcription (NFKB1) and cytokine production (IFNG, IL8 and IL10) were all investigated by real time qRT-PCR. This evidence concerns the gene TLR4 and tuberculosis.