CCND1 and endometrial cancer: Endometrial cancer is the most common cancer in women with HNPCC and the second most common cancer overall in this syndrome [22], therefore the association of the cyclin D1 870 G>A polymorphism and a family history of colorectal cancer is intriguing and suggests that this polymorphism may be related to the increased risk of endometrial cancer in HNPCC.