Endometrial cancer is the most common cancer in women with HNPCC and the second most common cancer overall in this syndrome [22], therefore the association of the cyclin D1 870 G>A polymorphism and a family history of colorectal cancer is intriguing and suggests that this polymorphism may be related to the increased risk of endometrial cancer in HNPCC. This evidence concerns the gene CCND1 and cancer.