GPNMB was chosen because it is a null mutation in the DBA/2J mouse strain, which develops iris pigment dispersion syndrome and iris stromal atrophy; the former was mapped to a premature stop mutation in GPNMB [64,65]; NEFH and GAP43 were chosen because they are markers of axonal regrowth [66,67], which has not been previously described in a primate glaucoma model. The gene discussed is GAP43; the disease is glaucoma.