In this study we analyzed the presence of RASSF1A protein within the primary tumor of clear cell RCCs and benign surrounding peritumoral tissues using immunohistochemistry (IHC) and tissue microarrays (TMA) and statistically evaluated possible associations of RASSF1A protein immunopositivity and clinicopathological parameters of RCC patients. The gene discussed is RASSF1; the disease is renal cell carcinoma.