Further concordance of RIα and RIIβ regulated genes was demonstrated with other empirically derived gene expression signatures related to cancer and cancer progression, including, for example, the down-regulation of genes in RIIβ cells related to DNA replication (E2F1_DNA_UP) [32], as well as to genes down-regulated following successful treatment of sarcoma cell lines with Ecteinascidin 743 (ET743_SARCOMA_DN) [33], and to p53-dependent down-regulation of gene expression in the ovarian cancer cell line 2774 following the ectopic expression of p21(CDKN1A) (P21_P53_ANY or MIDDLE_DN) [34]. The gene discussed is CDKN1A; the disease is cancer.