TUSC3 has since been shown to be hypermethylated in acute lymphoblastoid leukemia (ALL) cells [55], as well as in cervical intraepitelial neoplasia [56], and to be specifically associated with loss of heterozygosity (LOH) on chromosomal band 8p22, a common event in several epithelial tumors including ovarian carcinoma [41]. Here, TUSC3 is linked to ovarian carcinoma.