This, in conjunction with knowledge that most of the sequences identified were sometimes hypermethylated in NPTs and most were previously classified as Class B-II genes (those whose regulation by methylation is important for lineage specification and that present aberrant methylation in cancer), suggests that the genes hypermethylated in CD34+ progenitor cells that become unmethylated during differentiation are those primarily involved in lineage specification. Here, CD34 is linked to cancer.