Another top ranked gene set: “Genes up-regulated by MYC in P493-6 (B-cell)” (p = 5.43E-7, FDR q-value = 3.45E-5), may be also consistent with the previous observation as to the presence of varying amount of B-cells within these tumors [42] and the fact that c-MYC is a proto-oncogene that is commonly activated in a variety of human tumors and has been shown to promote tumor angiogenesis [44]. Here, MYC is linked to neoplasm.