The additional terms uncovered by SLEPR: “mitochondrial genes” and “PGC related genes”, which were absent from the GSEA results and have strong biological relevance with the previously identified and validated term “oxidative phosphorylation”: the mitochondria are well known as the cellular compartment where the oxidative phosphorylation reactions occur and PGC (or PGC-1)-responsive genes involved in oxidative-phosphorylation are coordinately downregulated in human diabetes [23]. The gene discussed is PGC; the disease is diabetes mellitus.