It should be noted that in our experiments the maximal amount of cleavage by pro-protein convertases never exceeded 15% of the total amount of sema3s found in the conditioned medium of producing tumor cells, and in the case of sema3E the cleavage was almost undetectable in both MDA-MB-231 and MDA-MB-435 cells, suggesting that the inhibitory effects that we observed are due to the effects of full length sema3E. Here, SEMA3E is linked to neoplasm.