In contrast, expression of sema3A did not inhibit tumor development (Fig. 4, A–B), while sema3D which binds to both neuropilins [26], significantly inhibited tumor development from the MDA-MB-435 cells though less potently than sema3G (Fig. 4, C–D) which may be due to the lower expression levels obtained with sema3D in these cells (Fig. 2B). This evidence concerns the gene SEMA3A and neoplasm.