In this study, Msurvivin T34A plasmid could induce obvious apoptosis of murine endothelial cells (MS1) in vitro, CD31 staining of Msurvivin T34A plasmid treated group showed the decrease of the number of intratumoral microvessel in vivo and alginate-encapsulated tumor cells test also confirmed that Msurvivin T34A plasmid could indeed affect angiogenesis. The gene discussed is PECAM1; the disease is neoplasm.