Until now, this association was shown with the Wnt pathway in arthritic mice, in which inhibition of TNF decreased the expression of Dickkopf, a Wnt antagonist, known for its neutralizing effect on anabolic mechanisms while supporting catabolic pathways of joint destruction [29], and with melanoma inhibitory activity in RA patients, a chondrocyte-specific molecule with anabolic characteristics, which has a decreased expression under pro-inflammatory cytokine conditions [30]. This evidence concerns the gene TNF and rheumatoid arthritis.