On the other hand, other evidence suggests that IgE could play a role in the pathogenesis of malaria; for example: a) there is an increase of the levels of IgE among individuals suffering from severe malaria in comparison to uncomplicated malaria [17,57-59]; b) IgE deposits were found in brain microvessels and on parasited erythrocytes from cerebral malaria patients [19] and in placentas infected with P. falciparum [20]. Here, IGHE is linked to malaria.