IgG, IgG1, IgG2, IgG3, IgG4, IgM, IgA and IgE isotypes levels were tested in P. falciparum blood-stage antigens of 233 Plasmodium-infected subjects presenting different clinical expressions of malaria: complicated malaria (CM), uncomplicated malaria (UM) and asymptomatic malaria (AS). This evidence concerns the gene CD40LG and malaria.