The number of previous clinical malaria attacks was positively correlated with IgG, IgG1 (Sp, r = 0.51; P = 0.00), IgG2 (Sp, r = 0.43; P = 0.00) and IgG3 (Sp, r = 0.33; P = 0.00), and negatively correlated with IgG4 (Sp, r = -0.23; P = 0.001). This evidence concerns the gene IGHG3 and malaria.