In starved mice, the mRNA for amember of the FOXO family, FKHR (forkhead homolog in rhabdomyosarcoma), isupregulated rapidly and transiently (starting within 6 hours, peaking at 12 hours,and decreasing at 24 hours), and this is followed by an upregulation of FKHRprotein and a nuclear accumulation of nonphosphorylated FKHR levels with aconsequent upregulation of its target gene pyruvate dehydrogenase kinase 4(PDK4) [44]. Here, FOXO1 is linked to rhabdomyosarcoma.