More than 10years ago, Ständer et al. [36] have shown that inhibition of TGF-β signalingby decorin increases the number of B and T cells (CD45+), T helper cells(CD4+), cytotoxic T cells (CD8+), and, most prominently, of activated T cells(CD25+) infiltrating the tumor in an intracerebral C6 rat glioma model. This evidence concerns the gene TGFB1 and central nervous system cancer.