This study reports that Activin A, a protein abundantly produced in the skin during normal and pathological wound healing [40]; [47] and inflammatory/autoimmune diseases (this study), induces the differentiation of human CD14+ monocytes in Langerin+, Birbeck granules+, E-cadherin+, CLA+ and CCR6+ cells. Here, SELPLG is linked to autoimmune disease.