Possible underlying biologic mechanisms by which insulin resistance may cause colorectal cancer include stimulating proliferation and reducing apoptosis in colon cells, inducing change in cell signalling pathways, such as protein kinase-C and mitogen-activated protein kinase, and alterering the insulin growth factor system, which is responsible for cell growth and differentiation (reviewed by Gunter and Leitzmann, 2006). The gene discussed is WNK2; the disease is colorectal cancer.