Lupus moDCs, however, exhibited decreased uptake of FD, both before (percentage uptake: control (n = 20), 83.1 ± 3.2 versus SLE (n = 47), 63.9 ± 3.9; P = 0.003; Figure 1a,c) and after stimulation with LPS and TNFα (percentage uptake: control (n = 13), 83.1 ± 5.8 and SLE (n = 30), 64.6 ± 6.5; P = 0.05; Figure 1b). This evidence concerns the gene TNF and systemic lupus erythematosus.