Our results wereconsistent with the previous works on human adrenocortical cancer cell lineH295R [14], pancreatic cancer cells [15], and human myeloid leukemia cells [16], whichshowed that PPARγ ligands act independently of PPARγ activation in the invasionsuppression and down-regulation of MMP-2 activity. This evidence concerns the gene PPARG and familial pancreatic carcinoma.