PGR and neoplasm: Interestingly, in ER-negative and PR-negative tumours expressing HMG-CoAR (n = 40), a negative/low expression of HER2 (immunohistochemistry 0 to 2) was associated with a significantly shorter RFS (RR = 3.92, 95%CI 1.25 to 12.36, p = 0.02), but not BCSS (data not shown), compared with tumours with high expression of HER2 (immunohistochemistry 3).