CDK4 and melanoma: The major aims of our study were: i) to determine the prevalence of germline CDKN2A mutations and variations in members of families with familial CM and in patients with multiple primary CM; ii) to search for individuals/families with possible CDK4 mutations; iii) to determine the frequency of MC1R gene variants and to correlate them with development of CM in the population of patients from melanoma families and their healthy relatives.