Other rare genetic causes of familial FTLD-U include mutations in the valosin containing protein gene (VCP) and the gene encoding the charged multivesicular body protein 2B (CHMP2B), while some families with a combination of FTLD and ALS show genetic linkage to a locus on chromosome 9p [25]–[29]. This evidence concerns the gene VCP and amyotrophic lateral sclerosis.