In the present study consisting of a cohort of affected sibling pairs selected from Asian Indian families with a strong history of premature CAD, the APOC3, Sac-1 and the ApoA1, -75G>A SNPs along with hypertension were the significant contributory factors to the CAD trait, probably mediated through their association with lipid and lipoprotein traits, particularly TC, TG and Apo B. This evidence concerns the gene APOB and Hypertension.