SACM1L and hypertensive disorder: In the present study consisting of a cohort of affected sibling pairs selected from Asian Indian families with a strong history of premature CAD, the APOC3, Sac-1 and the ApoA1, -75G>A SNPs along with hypertension were the significant contributory factors to the CAD trait, probably mediated through their association with lipid and lipoprotein traits, particularly TC, TG and Apo B.