SACM1L and coronary artery disorder: Given that this population has an inherent tendency for dyslipidemia and associated high risk of CAD [30], the objective of the present study was to estimate linkage and association between the 4 genetic variants, namely APOA1, -75G>A and +83C>T SNPs, the APOC3, Sac1 SNP and the APOA5, S19W SNP in the Apo11q gene cluster with premature CAD as well as with lipids and lipoproteins in a cohort of affected siblings belonging to Asian Indian families with strong history of CAD.