Preliminary studies on the APOC3-Sac1 polymorphism and plasma TG levels on 190 ASPs showed that the proportion of 0-, 1- and 2-alleles shared IBS, between the ASPs was 6.3%, 38.9% and 54.8%, respectively, which deviated significantly from the expected proportion of 25%, 50% and 25% allele sharing (P < 0.0001), suggesting tentative linkage of the Sac-1 locus with CAD (Figure 2A). This evidence concerns the gene SACM1L and irritable bowel syndrome.