We focused on the ADH4 gene in this study because of the functional importance of its protein product, remarkable for its activity at high ethanol concentrations that might be of particular relevance in the context of AD risk [2]; and because previous studies have demonstrated that ADH4 is an important risk gene for AD and AD-related traits in European-Americans (EAs) and African-Americans (AAs). Here, ADH4 is linked to Alzheimer disease.