The differences in the pre and perioperative characteristics of primary and secondary ovarian tumors have been studied by Antila et al [1], who found that tumors that were relatively smaller -10 cms sized; solid in nature; presenting with ascites; in association with raised serum CEA & tumor-associated trypsin (TAT-1) inhibitor levels, were predominantly metastatic. The gene discussed is CEACAM5; the disease is ovarian neoplasm.