Deficient inhibitory processing of the P50 auditory evoked potential is a pathophysiological feature of schizophrenia [3], [39]–[41] and Alzheimer's disease [42], and it has been suggested that α7 nAChRs play a critical role in this phenomenon [40], [41], [43], [44]. Here, CHRNA7 is linked to early-onset autosomal dominant Alzheimer disease.