Several lines of evidence suggest that α7 nAChRs play a role in the pathophysiology of neuropsychiatric diseases such as schizophrenia, Alzheimer's disease, anxiety, depression, and drug addiction, and that α7 nAChRs are the most attractive therapeutic targets for these diseases [3]–[11]. Here, CHRNA7 is linked to early-onset autosomal dominant Alzheimer disease.