Only a small number of genes were included in this study and the one reported by Rhee et al. To clearly discern the differences that exist between DNMT3b silenced PC3 and colon cancer cells, will require detailed gene expression as well as whole genome analysis in order to identify the sets of gene loci that are most impacted by DNMT3b silencing. The gene discussed is DNMT3B; the disease is colonic neoplasm.