DNMT3B and prostate cancer: To gain further insight into the consequences of DNMT3b silencing on the expression levels of various genes, a genechip array spotted with oligonucleotides representing a total of 288 (including 25 controls) genes found to be differentially expressed in prostate cancers was screened with biotin-labeled cRNA probes prepared from RNA that was purified from control and DNMT3b silenced PC3 cells (Figure-4A).