PRDM9 and Cornelia de Lange syndrome: These include BEAF-32, that encodes a chromatin insulator factor; dnk, that specifies a deoxyribonucleotide kinase similar to the human mitochondrial kinase TK2; Su(var)2-10, whose product is an E3 SUMO ligase; the H3.3B histone variant gene; SMC1, that encodes a conserved cohesin involved in the Cornelia de Lange syndrome in humans; Dcp-1, that specifies a caspase precursor; Megator (Mtor) that encodes a component of the putative spindle matrix; and CG17446, whose product is homologous to a subunit of the mammalian Set1 histone methyltransferase complex (Table S6).