The CC1 group includes Minichromosome maintenance 3 (Mcm3), Mcm7 and cap. Mcm3 and Mcm7 encode the orthologs of two components of the human (MCM)2-7 helicase complex (Table S6), while Cap encodes a protein orthologous to the SMC3 cohesin whose mutant form is responsible for a mild variant of the Cornelia de Lange syndrome [43]. The gene discussed is SMC3; the disease is Cornelia de Lange syndrome.