To our knowledge, tumour types highly vulnerable to rapalogues include endometrial cancer (Kanamori et al, 2001; Uegaki et al, 2005; Oza et al, 2006; Colombo et al, 2007; Milam et al, 2007) that frequently displays PTEN loss of function and mantle cell lymphoma (Grewe et al, 1999; Witzig et al, 2005; Ansell et al, 2006) that overexpress cyclin D1. The gene discussed is PTEN; the disease is mantle cell lymphoma.