In this study, also consistent with earlier works, increased tumour Ki-67 labelling index (Veronese et al, 1993; Scholzen and Gerdes, 2000; Trihia et al, 2003; Tsutsui et al, 2005) and microvessel density (Hansen et al, 2000a, 2000b; Uzzan et al, 2004; Tsutsui et al, 2005) were significantly associated with poorer cancer-specific survival. This evidence concerns the gene MKI67 and cancer.