In England, where prostate-specific antigen (PSA)-based screening is uncommon, the PRostate Cancer in Ethnic SubgroupS (PROCESS) study has demonstrated Black men to have 3.1 times the incidence of prostate cancer as compared with their same-age White counterparts (Ben-Shlomo et al, 2008). The gene discussed is KLK3; the disease is Familial prostate cancer.