As we have previously shown that EGCG+4-OHT produces an earlier and greater apoptotic response (Stuart et al, 2007) and elicits a greater inhibition of pEGFR in MDA-MB-231 cells (Stuart and Rosengren, 2007), the role of the EGFR and other downstream cell signalling proteins were determined in tumour extracts. Here, EGFR is linked to neoplasm.