The results demonstrated that protein expression of mTOR and S6K were significantly decreased in tumours from combination treatment mice as compared with all other treatment groups (relative density of mTOR was decreased by 78.0±6.9, 78.4±6.8 and 80.0±6.3% as compared with control, tamoxifen, and EGCG, respectively, P<0.001) (Figure 4A and B). This evidence concerns the gene MTOR and neoplasm.