Epidermal growth factor receptor signalling through the PI3K–Akt pathway results in the activation of the transcription factor nuclear factor-κB (NF-κB) (constitutively active in ERα− breast cancers) and mammalian target of rapamycin (mTOR), an important regulator of protein synthesis (Averous and Proud, 2006). Here, MTOR is linked to breast carcinoma.