SIGLEC1 and infection: The MAPK pathway is one of the most important pathways for immune response to infection (Bruder & Kovesdi, 1997; Yang et al., 2007) and has been found to be modulated in PAMs after an antibody-mediated cross-linking treatment of sialoadhesin, the main PRRSV internalization receptor (Genini et al., 2008), although in this case different genes of the pathway were involved.