Although it is well known that both AP-1 and NF-κB are activated in the lung after asbestos exposure (Haegens et al. 2007; Janssen et al. 1997; Mossman et al. 2000) and that MCP-1 is important in the initiation of atherosclerosis (Gosling et al. 1999), distal changes in AP-1 and NF-κB binding to DNA in the aorta after inhalation of asbestos are novel findings. Here, NFKB1 is linked to atherosclerosis.