Alterations in the phosphorylation of ERKs and p38 in NM cells were very minimal and occurred only at the 15-min time point, where both p38 and phosphorylated ERK1/2 (p-ERK1/2) showed significant phosphorylation in MM cells compared with NM cells (Figure 6B,C). The gene discussed is MAPK3; the disease is nemaline myopathy.