Particularly, the pathways of complement system, PPAR system, cell communication and Alzheimer's disease showed the significantly overall over-representation in diabetes serum (p<0.01), while insulin signaling, coagulation cascade, focal adhesion and long-term pathways presented significantly overall bias in non-diabetic serum (p>0.99) (Figure 3). This evidence concerns the gene INS and early-onset autosomal dominant Alzheimer disease.