In support of the immunotherapy approach is the finding that HCC cells overexpress the α-fetoprotein (AFP), NY-ESO-1, carcinoembryonic antigen (CEA), WT1, and glypican-3 as potential targets for the induction of antigen-specific cytotoxic T lymphocytes (CTL) responses [5-9]. Here, CEACAM5 is linked to hepatocellular carcinoma.