CD4 and hepatocellular carcinoma: Interestingly, fusions of immature DCs generated in the presence of HCC cell culture supernatants (HCCsp) and allogeneic HCC (DCs/allo-HCC/sp) induce dysfunction of the fused cells and promote the generation of CD4+ CD25high Foxp3+ Treg and impair the induction of antigen-specific CTL in the presence of the supernatants.