We also found that coculture of T cells with unirradiated DCs/allo-HCC/sp in the presence of HCCsp caused about 2-fold increase of CD25high+ Foxp3+T cells among all CD4+ T cells, as compared with those generated by unirradiated DCs/allo-HCC in the absence of HCCsp (Figure 4B). The gene discussed is FOXP3; the disease is hepatocellular carcinoma.