The model was also used to dissect the molecular pathogenesis of inflammatory CNS diseases such as multiple sclerosis, by determining the effect on myelin of cytokines such as tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interferon-γ (IFN-γ) (Woodroofe & Cuzner, 1993; Cannella & Raine, 1995; Navikas & Link, 1996; Lock et al., 2002). The gene discussed is TNF; the disease is multiple sclerosis.