In the enriched antigen presentation and integrin signaling pathways, we recognized significant roles of CALR, TAP1, HLA-DQB2, PTEN, HRAS, RHOA, ITGA3 and IT GA5 from the topological scorings and the differential gene activities in the evolving HNSCC transcriptome. This evidence concerns the gene CALR and head and neck squamous cell carcinoma.